One of the stand out locations used in Grimm actually has been seen on a couple episodes.
Part of the interior is the Wesen Retirement home and the outside, well for bake sales
The First Presbyterian Church is a striking building. Construction was completed in 1890. People traveling through the area can't help but notice the Gothic stonework and elegant windows.
Yet there is something about it that under the right lighting...
one can see why it might be considered for stories a little more dark.
Perhaps it's the tall bell tower.
Hard to argue after seeing this that the city is not a character on the show. It really does make a difference.